HPVsim is a stochastic agent-based model designed for simulating and analyzing the transmission of human papillomavirus (HPV). The model incorporates country-specific vital dynamics, structured sexual networks, co-transmitting HPV genotypes, B- and T-cell mediated immunity, and high-resolution disease natural history. Part of the Starsim suite, HPVsim enables rapid, highly customizable, and detailed exploration of HPV transmission and intervention strategies, making it an essential tool for public health research.
Features
Features of HPVsim include:
- Stochastic agent-based model: HPVsim is designed as a stochastic, agent-based model, focused on simulating the transmission dynamics of human papillomavirus (HPV).
- Highly customizable: The model allows users to flexibly define products and interventions, providing a clean pipeline for the rapid analysis of HPV and cervical cancer elimination strategies in different regions and research contexts.
- Immune response modeling: HPVsim includes the ability to simulate B- and T-cell mediated immunity, giving a detailed look at immune responses during HPV transmission and infection.
- High-resolution disease natural history: The model captures the intricate details of HPV’s natural history, offering high-resolution simulations for in-depth analysis.
Our approach
Our approach with HPVsim centers on providing a powerful yet user-friendly tool for HPV research. Implemented in Python, HPVsim combines high flexibility with ease of use, allowing users to quickly parameterize the model for specific scenarios and run simulations in seconds to minutes on a standard laptop. We emphasize both accuracy and usability, ensuring that the model accommodates complex epidemiological dynamics while remaining accessible to a broad range of users.
