Featured Research
EXPLORE IDM’S CURRENT RESEARCH GROUPS
The research and modeling team at IDM is focused on providing support to disease eradication programs and other global health endeavors through a variety of modeling and statistical approaches. We build mechanistic agent-based models in order to understand model assumptions and input data, examine the effects of population-level and within-host phenomena, and stimulate the impact of combined interventions, especially for all phases of an eradication effort.
The Computational Science Research (CSR) team develops algorithmic tools to increase the capability, usability, and efficiency of modeling methodology in support of stakeholders at IDM and partner organizations. CSR conducts novel and translational research to support the use of data and models in making better decisions regarding health and development. In addition to algorithm development, we support application and refinement of these methods in partnership with programmatic teams within IDM and beyond. Key initiatives within CSR include the following:
- Calibration - propagating structural and parametric uncertainty when fitting stochastic models like EMOD to historical data.
- Optimization - local and global numerical methods to find the best parameters or mix of interventions.
- Exploration - efficiently find interesting regions of parameter space.
- Design - efficiently use super-computing resources to achieve a simulation-based objective.
- AI-based approaches to health and development planning under uncertainty, with a focus on the value of information.
Dennis Chao , Edward Wenger , Joshua Proctor , Roman Levin, Dennis L Chao, Edward A Wenger, Joshua L Proctor
Nature Computational Science
Atiye Alaeddini, Kristi A.Morgansen, Mehran Mesbahi
Systems & Control Letters
Bulletin of Mathematical Biology
Atiye Alaeddini, Siavash Alemzadeh, Afshin Mesbahi, and Mehran Mesbahi
arXiv preprint arXiv:1807.06611
Isobel Routledge, José Eduardo Romero Chevéz, Zulma M. Cucunubá, Manuel Gomez Rodriguez, Caterina Guinovart, Kyle B Gustafson, Kammerle Schneider, Patrick G.T. Walker, Azra C. Ghani, Samir Bhatt
Nature Communications
Joshua Proctor , Kyle B. Gustafson, Joshua L. Proctor
arXiv.org q-bio
Daniel Klein , Atiye Alaeddini, and Daniel J Klein
Proceedings of the 2017 Winter Simulation Conference
Neil Sherborne, Joel C. Miller, Konstantin B. Blyuss, Istvan Z. Kiss
Journal of Mathematical Biology
Kyle Gustafson, Basil Bayati, Philip Welkhoff
Fractional Diffusion Emulates a Human Mobility Network during a Simulated Disease Outbreak
Atiye Alaeddini, Kristi A. Morgansen, Mehran Mesbahi
2017 American Control Conference (ACC)
Infectious Disease Modeling
Min K. Roh & Bernie J. Daigle Jr.
BMC Systems Biology
Physical Review E
Atiye Alaeddini, Kristi A. Morgansen
American Control Conference (ACC)
Physical Review E
Kyle B. Gustafson, Basil S. Bayati, Philip A. Eckhoff
arXiv.org, Cornell University Library
Basil S. Bayati
arXiv.org, Cornell University Library
Joshua Proctor , Joshua Proctor, S. L. Brunton, B. W. Brunton, J. N. Kutz
EPJ
Min K Roh and Philip Eckhoff
BMC Systems Biology
Daniel Klein , Daniel J. Klein, Michael Baym, and Philip Eckhoff
PLoS ONE
Joshua Proctor , B. W. Brunton, S. L. Brunton, J. L. Proctor, J. N. Kutz
arXiv.org, Cornell University Library
Hao Hu, Karima Nigmatulina, and Philip Eckhoff
Mathematical Biosciences
Basil Bayati
The Journal of Chemical Physics
Basil S. Bayati and Philip A.Eckhoff
Physical Review E
The Data, Dynamics, and Analytics (DDA) team is focused on applying modern data science, machine-learning, and statistical techniques to a wide-range of data including infectious disease data, household survey data, and genomic surveillance data. We aim to leverage the growing success of modern analytic and numerical methods as well as developing new mathematical methodologies tailored to the types of data being collected in resource-constrained settings. The primary goal is to help with near-term public policy questions facing the global health community.
Some areas of interest include:
- Collaborating with IDM disease teams to enable the usage of advanced analytic and numerical techniques;
- Investigating genomic and other molecular surveillance data to inform decisions on intervention and elimination strategies;
- Developing new mathematical techniques to analyze high-dimensional, timeseries data to construct models and forecast;
- Integrating geospatial data into mechanistic and equation-free dynamic modeling;
- Incorporating small area estimation methodologies with complex survey data for Family Planning indicators in resource-constrained settings.
Dennis Chao , Joshua Proctor , Ben J Brintz, Benjamin Haaland, Joel Howard, Dennis L Chao, Joshua L Proctor, Ashraful I Khan, Sharia M Ahmed, Lindsay T Keegan, Tom Greene
eLife
Navideh Noori , Mollie Van Gordon , Brittany Hagedorn , Edward Wenger , Andre Lin Ouedraogo , Laura Skrip, Karim Derra, Mikaila Kaboré, Navideh Noori, Adama Gansané, Innocent Valéa, Halidou Tinto, Bicaba W. Brice, Mollie Van Gordon, Brittany Hagedorn, Hervé Hien, Benjamin M. Althouse, Edward A. Wenger, André Lin Ouédraogo
International Journal of Infectious Diseases
Christopher Lorton , Joshua Proctor , Christopher W. Lorton, Joshua L. Proctor, Min K. Roh, Philip A. Welkhoff
CMSB
Joshua Proctor , Isobel Routledge, Shengjie Lai, Katherine E Battle, Azra C Ghani, Manuel Gomez Rodriguez, Kyle B Gustafson, Swapnil Mishra, Joshua L Proctor, Andrew J Tatem, Zhongjie Li, Samir Bhatt
biorxiv
Christopher Lorton , Joshua Proctor , Christopher W. Lorton, Joshua L. Proctor, Min K. Roh, Philip A. Welkhoff
BioRxiv
Joshua Proctor , Zhe Bai, Eurika Kaiser, Joshua L. Proctor, J. Nathan Kutz, and Steven L. Brunton
AIAA Journal
Joshua Proctor , N. M. Mangan , T. Askham , S. L. Brunton , J. N. Kutz and Joshua L. Proctor
Proceedings of the Royal Society A
Joshua Proctor , Laina D. Mercer, Fred Lu, Joshua L. Proctor
arXiv
Joshua Proctor , Niall M Mangan, Travis Askham, Steven L Brunton, J Nathan Kutz, Joshua L. Proctor
arXiv
Joshua Proctor , Joshua L. Proctor, Steven L. Brunton, J. Nathan Kutz
SIAM journal of Applied Dynamical systems
Joshua Proctor , Zhe Bai, Eurika Kaiser, Joshua L. Proctor, J. Nathan Kutz, Steven L. Brunton
AIAAJ
Joshua Proctor , Steven L. Brunton, Bingni W. Brunton, Joshua L. Proctor, Eurika Kaiser & J. Nathan Kutz
Nature Communications
Joshua Proctor , Samuel H. Rudy, Steven L. Brunton, Joshua L. Proctor, and J. Nathan Kutz
Science Advances
Joshua Proctor , Samuel H. Rudy, Steven L. Brunton, Joshua L. Proctor and J. Nathan Kutz
Science Advances
Joshua Proctor , Steven L. Brunton, J. Nathan Kutz, and Joshua L. Proctor
SIAM News
Joshua Proctor , James M. Kunert, Joshua L. Proctor, Steven L. Brunton, J. Nathan Kutz
PLOS
Joshua Proctor , Niall M. Mangan, J. Nathan Kutz, Steven L. Brunton, Joshua L. Proctor
arXiv.org
Joshua Proctor , Steven L. Brunton, Joshua L. Proctor, J. Nathan Kutz
IFAC-PapersOnLine
Joshua Proctor , Steven L. Brunton, Joshua L. Proctor, and J. Nathan Kutz
AIMS
Joshua Proctor , Joshua L. Proctor, Steven L. Brunton, and J. Nathan Kutz
EPJ
Joshua Proctor , B. W. Brunton, S. L. Brunton, Joshua L. Proctor, and J. N. Kutz
SIAM Journal of Applied Mathematics
Joshua Proctor , J. Nathan Kutz, Joshua L. Proctor, and Steven L. Brunton
arXiv
Joshua Proctor , Niall M. Mangan, Steven L. Brunton, Joshua L. Proctor, J. Nathan Kutz
IEEE Transactions on Molecular, Biological, and Multi-Scale Communications
Joshua Proctor , Steven L. Brunton, Joshua L. Proctor and J. Nathan Kutz
PNAS
Joshua Proctor , Steven L. Brunton, Bingni W. Brunton, Joshua L. Proctor, J. Nathan Kutz
PLoS ONE
Joshua Proctor , Joshua L. Proctor, S. L. Brunton, B. W. Brunton, J. N. Kutz
SIAM Journal on Applied Dynamical Systems
Joshua Proctor , Steven L. Brunton, Bingni W. Brunton, Joshua L. Proctor, J. Nathan Kutz
arXiv.org, Cornell University Library
Joshua Proctor , Steven L. Brunton, Joshua L. Proctor, J. Nathan Kutz
arXiv.org, Cornell University Library
Joshua Proctor , Joshua L. Proctor, Philip A. Eckhoff
International Health
Joshua Proctor , Matthew O. Williams, Joshua Proctor, J. Nathan Kutz
Physica D
Joshua Proctor , Joshua L. Proctor, S. L. Brunton, B. W. Brunton, J. N. Kutz
arXiv.org, Cornell University Library
Joshua Proctor , Steven L. Brunton, Joshua L. Proctor, and J. Nathan Kutz
arXiv.org, Cornell University Library
The enterics research program at IDM provides analytic support to research, policy, and implementation partners on a range of diseases, including typhoid fever, cholera, and a variety of pathogens responsible for childhood diarrhea.
Our typhoid research centers on questions of elimination feasibility and impact forecasting under different vaccination and WASH strategies. To support these efforts, we use mathematical modeling to describe mechanistically how different transmission routes -- human-to-human contact vs. environmental -- relate to setting-specific patterns of disease incidence, specifically spatial clustering, age patterns, environmental surveillance, and genetic signatures. For more information on typhoid research, please contact Jillian Gauld.
Our cholera research has focused on building spatial dynamical models of disease transmission and evaluating vaccine efficacy profiles to inform policy in endemic settings and outbreak scenarios. For more information on cholera research, please contact Dennis Chao.
More broadly, our research on diarrhea, a leading cause of childhood mortality, has explored the age and seasonal dependence of different viral, bacterial, and protozoal pathogens across numerous geographic settings. The goal has been to elucidate complex epidemiological pathogens, inform improved clinical decision-making, and contextualize the information-value of different diagnostic characteristics.
Some areas of work include:
- Typhoid risk factors in Malawi
- Seasonality of Diarrheal Pathogens
- Efficacy of Cholera Vaccine
- MDR non-typhoid salmonella in Kenya
Dennis Chao , Joshua Proctor , Ben J Brintz, Benjamin Haaland, Joel Howard, Dennis L Chao, Joshua L Proctor, Ashraful I Khan, Sharia M Ahmed, Lindsay T Keegan, Tom Greene
eLife
Dennis Chao , Joshua Proctor , Dennis L. Chao, Anna Roose, Min Roh, Karen L. Kotloff, Joshua L. Proctor
PLos NTDs
Joshua Proctor , Dennis Chao , Dennis L Chao, Anna Roose, Min Roh, Karen L Kotloff, Joshua L. Proctor
bioarxiv
Dennis Chao , Youyi Fong, M. Elizabeth Halloran, Jin Kyung Park, Florian Marks, John D. Clemens and Dennis L. Chao
BMC Infectious Diseases
Dennis Chao , Thomas J. Hladish, Carl A. B. Pearson, Dennis Chao, Diana Patricia Rojas, Gabriel L. Recchia, Héctor Gómez-Dantés, M. Elizabeth Halloran, Juliet R. C. Pulliam, Ira M. Longini
PLOS Neglected Tropical Diseases
For rapidly evolving pathogens, evolution complicates infectious disease control. Pathogen evolution can be thought of as taking place in a complex landscape influenced by the interactions between pathogen and host genetics, ecology, and epidemiology. This mandates an interdisciplinary approach that combines ideas from these fields into unified models.
At IDM, we focus on using dynamic, evolutionary disease transmission models to study evolutionary epidemiology phenomena. Specifically, we seek to model the emergence and spread of infectious diseases in realistic settings where natural selection, genetic drift, and genetic recombination/reassortment play key roles in the epidemic process.
We believe this approach will result in better disease management and public health policies in situations where interventions influence and are influenced by pathogen evolution. Although related to genomic epi, our work on evolutionary epi focuses on the dynamics of phenotypic evolution and is not solely focused on modeling sequencing data. Currently, our primary focus is modeling the emergence of cVDPV following mOPV2 administration. Future areas of interest include zoonotic emergence, drug resistance management, and CRISPR/CAS mutations.
The family planning team at the Institute for Disease Modeling is dedicated to informing decision-making to help achieve global goals to increase access to affordable, effective, and safe family planning services. Ensuring universal access and meeting demand for family planning services is integral to achieving gender equality, increasing economic empowerment, and improving health outcomes. We utilize data-driven approaches, such as dynamic modeling, statistical analyses, and machine-learning, to help characterize the current challenges facing the family planning community. Moreover, our analytic approaches leverage existing data to support policy and funding decisions in resource-constrained settings. We collaborate with governmental and non-governmental agencies as well as in-country partners to ensure analyses are directly relevant to informing family planning interventions and optimizing their implementation.
Joshua Proctor , Laina D. Mercer, Fred Lu & Joshua L. Proctor
BMC Public Health
The genomic epidemiology research program at IDM analyzes pathogen genomic data, in the context of other routine surveillance data, to resolve characteristics of disease transmission and enable improved programmatic decision-making. To support these efforts, we are researching improved methods for genetic-feature engineering, approximate
Bayesian inference, and forward-simulation platforms. Focus areas for applications of this work include malaria, polio, flu, typhoid, HIV, and Ebola.
For more information on the following topics, please contact:
- Malaria – Josh Proctor and Albert Lee
- Polio – Steve Kroiss, Wesley Wong, Mike Famulare
- Flu – Greg Hart, Rafael Nunez, Mike Famulare
Some areas of work include:
- Identifying Spatiotemporal Dynamics of Ebola in Sierra Leone Using Virus Genomes
- Modeling Malaria Genomics Reveals Transmission Decline and Rebound in Senegal
Joshua Proctor, Principal Research Scientist
Mike Famulare, Principal Research Scientist
Jillian Gauld, Research Scientist
Steve Kroiss, Sr. Research Scientist
Albert Lee, Research Scientist
Wesley Wong, Postdoctoral Research Scientist
Gregory Hart, Research Scientist
Rafael Nunez, Research Scientist
Bradley H. Wagenaar, Orvalho Augusto, Kristjana Ásbjörnsdóttir, Adam Akullian, Nelia Manaca, Falume Chale, Alberto Muanido, Alfredo Covele, Cathy Michel, Sarah Gimbel, Tyler Radford, Blake Girardot, Kenneth Sherr
International Journal of Health Geographics
Edward Wenger , Sean M. Moore, Quirine A. ten Bosch, Amir S. Siraj, K. James Soda, Guido España, Alfonso Campo, Sara Gómez, Daniela Salas, Benoit Raybaud, Edward Wenger, Philip Welkhoff and T. Alex Perkins
BMC Medicine
Adam Akullian , Adam Akullian , Joel M. Montgomery, Grace John-Stewart, Samuel I. Miller, Hillary S. Hayden, Matthew C. Radey, Kyle R. Hager, Jennifer R. Verani, John Benjamin Ochieng, Jane Juma, Jim Katieno, Barry Fields, Godfrey Bigogo, Allan Audi, Judd Walson
PLOS Neglected Tropical Diseases
The health delivery research program at IDM provides research and analysis in support of global, country-level, and subnational health delivery goals and strategy, with particular emphasis on immunization. This research is concerned with quantitative analysis of health outcomes and delivery goals in relation to existing health delivery systems, interventions, programs, policies, and socioeconomic drivers. We achieve these research aims with a team of diverse expertise, with statistical, health economic, and cost modeling of datasets and synthesis of scientific evidence. We encourage you to reach out to our team to learn more and collaborate.
Current projects in our research portfolio include:
- Health equity analysis; patterns, prospects, efficiency, and evidence for health equity goals
- Socioeconomic drivers of routine immunization
- Health system strengthening interventions
- Drivers of health system access and effectiveness (e.g. behaviors, access to care, workforce, structures)
Our health economics team aims to enhance ongoing disease modeling research by exploring additional factors relevant to makers, such as budget or logistical constraints, trade-offs between intervention strategies, or non-health outcomes. We focus on projects with real-time use by and application for decision maker, and translation into policy decisions. Decision makers are under continuous pressure to demonstrate greater accountability for how limited health resources are used to meet health system goals, which is an interconnected and time-dependent decision process.
There is a substantial body of published research on the cost-effectiveness of individual interventions in the global health and infectious disease areas, but there are practical and methodological challenges that limit the application of this research. At IDM we strive to extend this existing body of research by linking finance and disease modeling methods. We often do so by integrating health economics methods with the results of robust disease transmission models developed by IDM’s disease modeling teams.
Several key methodologies include:
- Cost-effectiveness and cost-utility analyses (CEA/CUA): Using these models, we incorporate the costs of vaccination, treatment, implementation, or other features to compare multiple intervention strategies in terms of value for money. We focus on making these models relevant to the questions asked by decision makers and presented in a user-friendly format or tool.
- Value of Information or data (VoI): These methods are used to qualify the impact of uncertainty in decision making. VoI combines the uncertainty in modeling and data with the impact of decisions to define the need of more accurate data. VoI can also be applied to data needs, such as disease surveillance, quantify the value or investing in data acquisition interventions instead of or in addition to other health interventions.
- Program budgeting and marginal analysis (PMBA): This type of analysis can be used to make recommendations for optimizing a portfolio or program under a budget constraint. It incorporates locally relevant decision-making criteria, multi-criteria decision analysis, investments and disinvestments, and aligns options with each specific analysis.
Brittany Hagedorn , Jillian Gauld , Brittany L. Hagedorn, Jillian Gauld, Nicholas Feasey, Hao Hu
Vaccine
Marita Zimmermann , Kurt Frey , Brittany Hagedorn , Kevin McCarthy , Guillaume Chabot-Couture , Marita Zimmermann, Kurt Frey, Brittany Hagedorn, A.J.Oteri, Abdulazeez Yahya, Maimuna Hamisu, Fred Mogekwu, Faisal Shuaib, Kevin A.McCarthy, Guillaume Chabot-Couture
Vaccine
Brittany Hagedorn , Kevin McCarthy , Brittany L. Hagedorn, Alya Dabbagh, Kevin A. McCarthy
Vaccine
Brittany Hagedorn , Wedlock PT, Mitgang EA, Oron AP, Hagedorn BL, Leonard J, Brown ST, Bakal J, Siegmund SS, Lee BY
Vaccine
The HIV research program at IDM provides analytical support to our research, policy, and implementation partners. These include estimates and forecasts of epidemic trends, as well as impact estimation for interventions that can be used to develop strategic plans, target product profiles, and field studies. To support these efforts, we have developed a very flexible individual-based modeling software tool, EMOD-HIV, for which source code and documentation are freely available online, and training is available on request both through IDM and our research collaborator network.
Current priorities for our research agenda include:
- Estimating demographic shifts in HIV burden and address these in resource-limited settings.
- Estimating the impact of emerging interventions such as pre-exposure prophylaxis, HIV self-testing, community-based treatment, and point-of-care patient monitoring.
Daniel Klein , Edinah Mudimu, Kathryn Peebles, Zindoga Mukandavire, Emily Nightingale, Monisha Sharma, Graham F. Medley, Daniel J. Klein, Katharine Kripke, Anna Bershteyn
PLOS One
Adam Akullian , Monisha Sharma, PhD, Edinah Mudimu, PhD Kate Simeon, MD, Anna Bershteyn, PhD, Jienchi Dorward, MBChB, Lauren R Violette, MPH, Adam Akullian, PhD, Prof Salim S Abdool Karim, MBBCH, Prof Connie Celum, MD, Nigel Garrett, MBBS, Paul K Drain, MD
The Lancet HIV
Adam Akullian , Anna Bershteyn, Monisha Sharma, Adam Akullian, Kathryn Peebles, Supriya Sarkar, R Scott Braithwaite, Edinah Mudimu
Journal of the International AIDS Society
Adam Akullian , Dan Bridenbecker , Adam Akullian , Michelle Morrison, Geoffrey P Garnett, Zandile Mnisi, Nomthandazo Lukhele, Daniel Bridenbecker, Anna Bershteyn
The Lancet HIV
Adam Akullian , Alain Vandormael, Adam Akullian, Mark Siedner, Tulio de Oliveira, Till Bärnighausen and Frank Tanser
Nature Communications
Adam Akullian , Carol Camlin, Adam Akullian, Torsten Neilands, Monica Getahun, Anna Bershteyn, Sarah Ssali, ElvinGeng, Monica Gandhi, Craig Cohen, Irene Maeri, Patrick Eyul, Maya L.Petersen, Diane Havlir, Moses Kamya, Elizabeth Bukusi, Edwin Charlebois
Health & Place
Adam Akullian , Dylan Green, Brenda Kharono, Diana M. Tordoff, Adam Akullian, Anna Bershteyn, Michelle Morrison, Geoff Garnett, Ann Duerr, Paul Drain
BMC
Adam Akullian , Diego F. Cuadros, Benn Sartorius, Chris Hall, Adam Akullian, Till Bärnighausen, Frank Tanser
International Journal of Health Geographics
Adam Akullian , Carol S Camlin, Adam Akullian, Torsten B Neilands, Monica Getahun, Patrick Eyul, Irene Maeri, Sarah Ssali, Elvin Geng, Monica Gandhi, Craig R Cohen, Moses R Kamya, Thomas Odeny, Elizabeth A Bukusi, Edwin D Charlebois
Journal of the International AIDS Society
Adam Akullian , Daniel Klein , Anna Bershteyn, Kennedy K Mutai, Adam Akullian, Daniel J Klein, Britta L Jewell, Samuel M Mwalili
Science Direct
Adam Akullian , Adam Akullian, Bershteyn, Anna, Jewell, Britta, Camlin, Carol S.
AIDS
Adam Akullian , Diego F. Cuadros, Jingjing Li, Adam J. Branscum, Adam Akullian, Peng Jia, Elizabeth N. Mziray, and Frank Tanser
Scientific Reports
Adam Akullian , Daniel Klein , Adam Akullian, Anna Bershteyn, Daniel Klein, Alain Vandormael, Till Barnighausen, and Frank Tanser
AIDS
Adam Akullian , Daniel Klein , Akullian, Adam PhD, Onyango, Mathews MPH, Klein, Daniel PhD, Odhiambo, Jacob MBChB, Bershteyn, Anna PhD
Medicine
Daniel Klein , Anna Bershteyn, Daniel J. Klein, Philip A. Eckhoff
International Health
Adam Akullian , Adam M Akullian, Aggrey Mukose, Gillian A Levine, Joseph B Babigumira
Journal of the International AIDS Society
Daniel Klein , Dr Jeffrey W Eaton, Nicolas Bacaër, PhD, Anna Bershteyn, PhD, Valentina Cambiano, PhD, Anne Cori, PhD, Prof Rob E Dorrington, MPhil, Prof Christophe Fraser, PhD, Chaitra Gopalappa, PhD, Jan A C Hontelez, PhD, Leigh F Johnson, PhD, Daniel J Klein, PhD, Prof Andrew N Phillips, PhD, Carel Pretorius, PhD, John Stover, MA, Prof Thomas M Rehle, MD, Prof Timothy B Hallett, PhD
The Lancet Global Health
Daniel Klein , Gesine Meyer-Rath, Mead Over, Dan Klein, Anna Bershteyn,
The Center for Global Development
Daniel Klein , Daniel J. Klein, Philip A. Eckhoff, Anna Bershteyn
International Health
Daniel Klein , Stewart Chang , Jeffrey W Eaton, PhD†, Nicolas A Menzies, MPH†, John Stover, MA, Valentina Cambiano, MS, Leonid Chindelevitch, PhD, Anne Cori, PhD, Jan A C Hontelez, PhD, Salal Humair, PhD, Cliff C Kerr, PhD, Daniel Klein, PhD, Sharmistha Mishra, MD, Kate M Mitchell, PhD, Brooke E Nichols, MS, Prof Peter Vickerman, DPhil, Roel Bakker, PhD, Till Bärnighausen, DSc, Anna Bershteyn, PhD, Prof David E Bloom, PhD, Marie-Claude Boily, PhD, Stewart T Chang, PhD, Ted Cohen, DPH, Peter J Dodd, PhD, Prof Christophe Fraser, PhD, Chaitra Gopalappa, PhD, Prof Jens Lundgren, DMSc, Natasha K Martin, DPhil, Evelinn Mikkelsen, MSc, Elisa Mountain, MSc, Quang D Pham, MD, Michael Pickles, PhD, Prof Andrew Phillips, PhD, Lucy Platt, PhD, Carel Pretorius, PhD, Holly J Prudden, MSc, Prof Joshua A Salomon, PhD, David A M C van de Vijver, PhD, Sake J de Vlas, PhD, Bradley G Wagner, PhD, Richard G White, PhD, David P Wilson, PhD, Lei Zhang, PhD, John Blandford, PhD, Gesine Meyer-Rath, PhD, Michelle Remme, MSc, Paul Revill, PhD, Nalinee Sangrujee, PhD, Fern Terris-Prestholt, PhD, Meg Doherty, PhD, Nathan Shaffer, MD, Prof Philippa J Easterbrook, MD, Gottfried Hirnschall, MD, Prof Timothy B Hallett, PhD
The Lancet Global Health
Daniel Klein , Dan Klein, Anna Bershteyn, and Philip Eckhoff
AIDS
Daniel Klein , Anna Bershteyn, Daniel J. Klein, and Philip A. Eckhoff
Journal of the Royal Society Interface
Anna Bershteyn & Philip A Eckhoff
BMC Systems Biology
Daniel Klein , Daniel J. Klein
2012 IEEE 51st Annual Conference on Decision and Control
Daniel Klein , Anna Bershteyn and Dan Klein
PLoS Medicine
Daniel Klein , Edward Wenger , Jeffrey W. Eaton, Leigh F. Johnson, Joshua A. Salomon, Till Bärnighausen, Eran Bendavid, Anna Bershteyn, David E. Bloom, Valentina Cambiano, Christophe Fraser, Jan A. C. Hontelez, Salal Humair, Daniel J. Klein, Elisa F. Long, Andrew N. Phillips, Carel Pretorius, John Stover, Edward A. Wenger, Brian G. Williams, and Timothy B. Hallett
PLoS Medicine
Daniel Klein , Edward Wenger , Anna Bershteyn, Daniel J. Klein, Edward Wenger, and Philip A. Eckhoff
arXiv.org
Transmitted by the bite of Anopheles mosquitoes, Plasmodium parasites are responsible for hundreds of millions of clinical malaria cases and half a million deaths every year. The Institute for Disease Modeling is committed to supporting global control and elimination strategy through our research. Whether through statistical analyses on surveillance data or the application of our individual-based microsimulation model of malaria transmission we are focused on understanding how to more efficiently reduce burden under limited resources, how to combine tools to achieve elimination, and how to design surveillance and response systems to maintain elimination. Working with programmatic, academic, and NGO partners around the world, our team is focused on the following:
- Understanding malaria infection dynamics across diverse settings, including the relationships between exposure, acquisition of immunity, symtomaticity, and human infectiousness.
- Understanding the spatio-temporal drivers of malaria mortality and optimizing intervention delivery to reduce morbidity and mortality in high-burden area.
- Understanding the nature and implications of heterogeneity in exposure, heterogeneity in intervention coverage and usage, and human migration patterns.
- Predicting the impact of new or developing technologies on malaria transmission
- Designing stratification schemes and operationally feasible intervention packages likely to achieve and maintain malaria elimination.
Edward Wenger, Deputy Director, Research Technology
Caitlin Bever, Sr. Research Manager
Andre Lin Ouedraogo, Sr. Research Scientist
Amelia Bertozzi-Villa, Sr. Research Scientist
Prashanth Selvaraj, Sr. Research Scientist
Josh Suresh, Research Scientist
Monique Ambrose, Sr. Research Scientist
Katherine Battle, Sr. Research Scientist
Shirley Leung, Postdoctoral Research Scientist
Katherine Battle , Angela Devine, Katherine E. Battle, Niamh Meagher, Rosalind E. Howes, Saber Dini, Peter W. Gething, Julie A. Simpson, Ric N. Price, Yoel Lubell
PLOS Medicine
Andre Lin Ouedraogo , Edward Wenger , André Lin Ouédraogo, Julie Zhang, Halidou Tinto, Innocent Valéa & Edward A. Wenger
BMC Health Services Research
Prashanth Selvaraj , Edward Wenger , Dan Bridenbecker , Caitlin Bever , Prashanth Selvaraj, Edward A. Wenger, Daniel Bridenbecker, Nikolai Windbichler, Jonathan R. Russell , Jaline Gerardin, Caitlin A. Bever, Milen Nikolov
BioRxiv
Prashanth Selvaraj , Emmanuel P. Mwanga, Elihaika G. Minja, Emmanuel Mrimi, Mario González Jiménez, Johnson K. Swai, Said Abbasi, Halfan S. Ngowo, Doreen J. Siria, Salum Mapua, Caleb Stica, Marta F. Maia, Ally Olotu, Maggy T. Sikulu-Lord, Francesco Baldini, Heather M. Ferguson, Klaas Wynne, Prashanth Selvaraj, Simon A. Babayan & Fredros O. Okumu
Malaria Journal
Prashanth Selvaraj , Josh Suresh , Edward Wenger , Caitlin Bever , Prashanth Selvaraj , Joshua Suresh, Edward A. Wenger, Caitlin A. Bever & Jaline Gerardin
Malaria Journal
Prashanth Selvaraj , Emmanuel P. Mwanga, Salum A. Mapua, Doreen J. Siria, Halfan S. Ngowo, Francis Nangacha, Joseph Mgando, Francesco Baldini, Mario González Jiménez, Heather M. Ferguson, Klaas Wynne, Prashanth Selvaraj, Simon A. Babayan & Fredros O. Okumu
Malaria Journal
Andre Lin Ouedraogo , Hannah C. Slater, Amanda Ross, Ingrid Felger, Natalie E. Hofmann, Leanne Robinson, Jackie Cook, Bronner P. Gonçalves, Anders Björkman, André Lin Ouédraogo, Ulrika Morris, Mwinyi Msellem, Cristian Koepfli, Ivo Mueller, Fitsum Tadesse, Endalamaw Gadisa, Smita Das, Gonzalo Domingo, Melissa Kapulu, Janet Midega, Seth Owusu-Agyei, Cécile Nabet, Renaud Piarroux, Ogobara Doumbo, Safiatou Niare Doumbo, Kwadwo Koram, Naomi Lucchi, Venkatachalam Udhayakumar, Jacklin Mosha, Alfred Tiono, Daniel Chandramohan, Roly Gosling, Felista Mwingira, Robert Sauerwein, Eleanor M Riley, Nicholas J White, Francois Nosten, Mallika Imwong, Teun Bousema, Chris Drakeley, Lucy C Okell
Nature Communications
Prashanth Selvaraj , Edward Wenger , Prashanth Selvaraj, Edward Wenger, and Jaline Gerardin
BMC Infectious Diseases
Andre Lin Ouedraogo , John M. Marshall, Sean L. Wu, Hector M. Sanchez C., Samson S. Kiware, Micky Ndhlovu, André Lin Ouédraogo, Mahamoudou B. Touré, Hugh J. Sturrock, Azra C. Ghani, Neil M. Ferguson
Scientific Reports
Andre Lin Ouedraogo , Edward Wenger , André Lin Ouédraogo, Philip A. Eckhoff, Adrian J. F. Luty, Will Roeffen, Robert W. Sauerwein, Teun Bousema, Edward A. Wenger
PLoS Pathogens
Amelia Bertozzi-Villa , Edward Wenger , Jaline Gerardin, Amelia Bertozzi-Villa, Philip A Eckhoff, Edward A. Wenger
International Health
Andre Lin Ouedraogo , Will J. R. Stone, Joseph J. Campo, André Lin Ouédraogo, Lisette Meerstein-Kessel, Isabelle Morlais, Dari Da, Anna Cohuet, Sandrine Nsango, Colin J. Sutherland, Marga van de Vegte-Bolmer, Rianne Siebelink-Stoter, Geert-Jan van Gemert, Wouter Graumans, Kjerstin Lanke, Adam D. Shandling, Jozelyn V. Pablo, Andy A. Teng, Sophie Jones, Roos M. de Jong, Amanda Fabra-García, John Bradley, Will Roeffen, Edwin Lasonder, Giuliana Gremo, Evelin Schwarzer, Chris J. Janse, Susheel K. Singh, Michael Theisen, Phil Felgner, Matthias Marti, Chris Drakeley, Robert Sauerwein, Teun Bousema, and Matthijs M. Jore
Nature communications
Wesley Wong , Edward Wenger , Wesley Wong, Edward A. Wenger, Daniel L. Hartl, Dyann F. Wirth
PLoS Computational Biology
Caitlin Bever , Dan Bridenbecker , Edward Wenger , Jaline Gerardin, Caitlin A. Bever, Daniel Bridenbecker, Busiku Hamainza, Kafula Silumbe, John M. Miller, Thomas P. Eisele, Philip A. Eckoff, and Edward A. Wenger
Malaria Journal
Edward Wenger , Oliver J Brady, Hannah C Slater, Peter Pemberton-Ross, Edward Wenger, Richard J Maude, Azra C Ghani, Melissa A Penny, Jaline Gerardin, Lisa J White, Nakul Chitnis, Ricardo Aguas, Simon I Hay, David L Smith, Erin M Stuckey, Emelda A Okiro, Thomas A Smith, Lucy C Okell
The Lancet
Edward Wenger , Philip Welkhoff, Edward Wenger, H. Charles J. Godfray, and Austin Burt
PNAS
Caitlin Bever , Edward Wenger , Milen Nikolov, PhD, Caitlin A. Bever, PhD, Alexander Upfill-Brown, Busiku Hamainza, John M. Miller, Philip A. Eckhoff, PhD, Edward A. Wenger, PhD, Jaline Gerardin, PhD
PLoS Computational Biology
Edward Wenger , Andrew M. Bellinger, Mousa Jafari, Tyler M. Grant, Shiyi Zhang, Hannah C. Slater, Edward A. Wenger, Stacy Mo, Young-Ah Lucy Lee, Hormoz Mazdiyasni, Lawrence Kogan, Ross Barman, Cody Cleveland, Lucas Booth, Taylor Bensel, Daniel Minahan, Haley M. Hurowitz, Tammy Tai, Johanna Daily, Boris Nikolic, Lowell Wood, Philip A. Eckhoff, Robert Langer, and Giovanni Traverso
Science Translational Medicine
Mara K. N. Lawniczak and Philip A. Eckhoff
Malaria Journal
Andre Lin Ouedraogo , John M. Marshall, Mahamoudou Touré, André Lin Ouédraogo, Micky Ndhlovu, Samson S. Kiware, Ashley Rezai, Emmy Nkhama, Jamie T. Griffin, T. Deirdre Hollingsworth, Seydou Doumbia, Nicodem J. Govella, Neil M. Ferguson and Azra C. Ghani
Malaria Journal
Caitlin Bever , Edward Wenger , Jaline Gerardin, Caitlin A. Bever, Busiku Hamainza, John M. Miller, Philip A. Eckhoff, Edward A. Wenger
PLoS Computational Biology
Andre Lin Ouedraogo , Hannah C. Slater, Amanda Ross, André Lin Ouédraogo, Lisa J. White, Chea Nguon, Patrick G.T. Walker, Pengby Ngor, Ricardo Aguas, Sheetal P. Silal, Arjen M. Dondorp, Paul La Barre, Robert Burton, Robert W. Sauerwein, Chris Drakeley, Thomas A. Smith, Teun Bousema, Azra C. Ghani
Nature
Caitlin Bever , Edward Wenger , Dr Melissa A Penny, PhD, Robert Verity, PhD, Caitlin A Bever, PhD, Christophe Sauboin, MA, Katya Galactionova, MA, Stefan Flasche, PhD, Michael T White, PhD, Edward A Wenger, PhD, Nicolas Van de Velde, PhD, Peter Pemberton-Ross, PhD, Jamie T Griffin, PhD, Prof Thomas A Smith, PhD, Philip A Eckhoff, PhD, Farzana Muhib, MPH, Mark Jit, PhD, Prof Azra C Ghani, PhD
The Lancet
Edward Wenger , S. Bhatt, D.J. Weiss, E. Cameron, D. Bisanzio, B. Mappin, U. Dalrymple, K. E. Battle, C. L. Moyes, A. Henry, P. A. Eckhoff, E. A. Wenger, O. Briët, M. A. Penny, T. A. Smith, A. Bennett, J. Yukich, T. P. Eisele, J. T. Griffin, C. A. Fergus, M. Lynch, F. Lindgren, J. M. Cohen, C. L. J. Murray, D. L. Smith, S. I. Hay, R. E. Cibulskis & P. W. Gething
Nature
Edward Wenger , Ewan Cameron, Katherine E. Battle, Samir Bhatt, Daniel J. Weiss, Donal Bisanzio, Bonnie Mappin, Ursula Dalrymple, Simon I. Hay, David L. Smith, Jamie T. Griffin, Edward. A. Wenger, Philip. A. Eckhoff, Thomas A. Smith, Melissa A. Penny, Peter W. Gething
Nature Communications
Andre Lin Ouedraogo , Caitlin Bever , Hil Lyons , André Lin Ouédraogo, Bronner P. Gonçalves, Awa Gnémé, Edward A. Wenger, Moussa W. Guelbeogo, Amathe Ouédraogo, Jaline Gerardin, Caitlin A. Bever, Hil Lyons, Xavier Pitroipa, Jan Peter Verhave, Philip A. Eckhoff, Chris Drakeley, Robert Sauerwein, Adrian J. F. Luty, Bocar Kouyaté, and Teun Bousema
The Journal of Infectious Diseases
Andre Lin Ouedraogo , Kevin McCarthy , Edward Wenger , Jaline Gerardin, André Lin Ouédraogo, Kevin A McCarthy, Philip A Eckhoff & Edward A Wenger
Malaria Journal
Caitlin Bever , Edward Wenger , Philip A Eckhoff, Caitlin Bever, Jaline Gerardin, Edward A Wenger, David L Smith
Science Direct
Edward Wenger , Joshua Proctor , Wesley Wong , Rachel F. Daniels, Stephen F. Schaffner, Edward A Wenger, Joshua Proctor, Hsiao-Han Chang, Wesley Wong , Nicholas Baro, Daouda Ndiaye, Fatou Ba Fall, Medoune Ndiop, Mady Ba, Danny A. Milner, Jr., Terrie E. Taylor, Daniel E. Neafsey, Sarah K. Volkman, Philip Eckhoff , Daniel L. Hartl, and Dyann F. Wirth
PNAS
Edward Wenger , Jaline Gerardin, Philip Eckhoff and Edward Wenger
BMC Infectious Diseases
Kevin McCarthy , Edward Wenger , Kevin McCarthy, Edward Wenger, Grace Huynh and Philip Eckhoff
Malaria Journal
Caitlin Bever , Edward Wenger , Philip Eckhoff, Caitlin Bever, Jaline Gerardin, and Edward Wenger
Malaria Journal
Guillaume Chabot-Couture , Guillaume Chabot-Couture, Karima Nigmatulina, and Philip Eckhoff
PLoS ONE
Joshua Proctor , Charles Delahunt, Matthew P Horning, Benjamin K Wilson, Joshua L Proctor, and Michael C Hegg
Malaria Journal
NCBI
Edward Wenger , Edward A Wenger & Philip A Eckhoff
Malaria Journal
Malaria journal
PLoS ONE
Malaria Journal
Philip Eckhoff
PLoS Medicine
Andre Lin Ouedraogo , David Kong , Edward Wenger , Karim Derra, Valea Innocent, Halidou Tinto, Abraham Flaxman, Hazard Riley
Christopher Lorton , Andre Lin Ouedraogo , Edward Wenger , Caitlin Bever , Bryan Greenhouse, Isabel Rodriguez-Barraquer, Jaline Gerardin
Edward Wenger , Caitlin Bever , John Miller, Busiku Hamainza, Jaline Gerardin
Joshua Proctor , Caitlin Bever , Peter Gething, Samir Bhatt, Jaline Gerardin,
Caitlin Bever , Victoria M Hunt, Christine M Bachman, David Cate, Bernhard H Weigl, David Bell, Chris Drakeley, Jaline Gerardin
A century ago, all around the world mothers dying near childbirth were a commonly occurring tragedy. Furthermore, nearly everyone knew of children in their family and social circle who had died very young. Since then, across most of the world such tragedies have now become rare events, with progress usually achieved via periods of rapid advance, e.g., Scandinavia and North America in 1920-1960, or China, Iran, and Turkey in 1970-2010. A belated focus is given in recent years to those parts of the world, mostly in Africa and South Asia, where - due to economic, environmental, and other challenges - the progress has yet to acquire critical momentum, and these family tragedies are still all too common.
IDM's Maternal, Newborn, and Child Health (MNCH) team is committed to help people in regions suffering from high burden of maternal and child mortality, to achieve rapid mortality reduction, and improve MNCH in general. We combine a holistic perspective, with specific collaborations that enable a razor-sharp focus on particular locations and interventions.
Our work includes:
- Identifying conditions and interventions that represent under-utilized or under-studied opportunities to accelerate MNCH improvements, and quantifying their potential impact. Then, partnering with researchers, health organizations on the ground, and governance and funding bodies, providing design and analysis support to strategies that leverage these opportunities.
- Partnering with stakeholders to investigate MNCH in particular settings, as well as specific interventions initiated/considered by these stakeholders and their impact.
- Investigating and developing improvements to systems that quantify MNCH trends on the ground, such as demographic surveillance districts and verbal autopsy systems.
- Partnering with IDM's Delivery, Health Economics and other teams, to produce quantitative analysis and advice on improvements to systems and policies for MNCH services, such as the Expanded Program on Immunization (EPI) and national primary-health networks.
Dennis Chao , Joshua Proctor , Ben J Brintz, Benjamin Haaland, Joel Howard, Dennis L Chao, Joshua L Proctor, Ashraful I Khan, Sharia M Ahmed, Lindsay T Keegan, Tom Greene
eLife
Amelie O von Saint Andre-von Arnim, Rashmi K Kumar, Assaf P. Oron, Quynh-Uyen P Nguyen, Daniel M Mutonga, Jerry Zimmerman, Judd L Walson
Pediatric Critical Care Medicine
Victoria Nembaware, Gaston K. Mazandu, Jade Hotchkiss, Jean-Michel Safari Serufuri, Jill Kent, Andre Pascal Kengne, Kofi Anie, Nchangwi Syntia Munung, Daima Bukini, Valentina Josiane Ngo Bitoungui, Deogratias Munube, Uzima Chirwa, Catherine Chunda-Liyoka, Agnes Jonathan, Miriam V. Flor-Park, Kevin Kum Esoh, Mario Jonas, Khuthala Mnika, Chandré Oosterwyk, Upendo Masamu, Jack Morrice, Annette Uwineza, Arthemon Nguweneza, Kambe Banda, Isaac Nyanor, David Nana Adjei, Nathan Edward Siebu, Malula Nkanyemka, Patience Kuona, Bamidele O. Tayo, Andrew Campbell, Assaf P. Oron, Obiageli E. Nnodu, Vivian Painstil, Julie Makani, Nicola Mulder, Ambroise Wonkam
OMICS
Dennis Chao , Assaf P. Oron, Dennis L. Chao, Echezona E. Ezeanolue, Loveth N. Ezenwa, Frédéric B. Piel, Osifo Telison Ojogun, Sophie Uyoga, Thomas N. Williams & Obiageli E. Nnodu
BMC Medicine
Steven Hawken ORCID Icon, Robin Ducharme, Deshayne B. Fell, Assaf P. Oron & Kumanan Wilson
Human Vaccines & Immunotherapies
Travis C. Porco, Catherine E. Oldenburg, Ahmed M. Arzika, Khumbo Kalua, Zakayo Mrango, Catherine Cook, Elodie Lebas, Robin L. Bailey, Sheila K. West, Assaf P. Oron, Jeremy D. Keenan, Thomas M. Lietman and for the MORDOR Study Group
ASTMH
Assaf P. Oron, Roy Burstein, Laina D. Mercer, Ahmed M. Arzika, Khumbo Kalua, Zakayo Mrango, Sheila K. West, Robin L. Bailey, Travis C. Porco and Thomas M. Lietman
ASTMH
Andre Lin Ouedraogo , David Kong , Edward Wenger , Karim Derra, Valea Innocent, Halidou Tinto, Abraham Flaxman, Hazard Riley
Despite a 90% reduction in estimated global mortality since the pre-vaccine era, measles remains a major contributor to global disease burden. Achieving measles eradication will require improved and targeted efforts to attain, verify, and maintain sufficient vaccination coverage in the most challenging areas of the world, development of sensitive disease surveillance systems, effective community engagement and intensified cross-country collaboration to synchronize local elimination efforts.
At IDM, we focus on developing dynamic models and analyzing a multitude of data sources to guide measles control programs from robust endemic transmission, through intensified surveillance and control, and on to regional elimination.
Our research is focused on three key areas:
- Assessment of data quality and program performance.
- Developing the dynamic models needed to define the requirements for measles eradication.
- Collaborating with country partners to reduce measles burden today.
Example projects include: Using EMOD and other dynamic models, along with cost models, to optimize the timing, frequency, and target group of planned vaccination campaigns; modeling measles transmission in the provinces of Pakistan to quantify the effect of delaying vaccination campaigns; and developing subnational risk assessment metrics from case-based surveillance for the WHO Southeast Asia Regional Office.
Niket Thakkar , Kevin McCarthy , Katy AM Gaythorpe, Kaja Abbas, John Huber, Andromachi Karachaliou, Niket Thakkar, Kim Woodruff, Xiang Li, Susy Echeverria-Londono, VIMC Working Group on COVID-19 Impact on Vaccine Preventable Disease, Matthew Ferrari, Michael L Jackson, Kevin McCarthy, T Alex Perkins, Caroline Trotter, Mark Jit
eLife
Marita Zimmermann , Kurt Frey , Brittany Hagedorn , Kevin McCarthy , Guillaume Chabot-Couture , Marita Zimmermann, Kurt Frey, Brittany Hagedorn, A.J.Oteri, Abdulazeez Yahya, Maimuna Hamisu, Fred Mogekwu, Faisal Shuaib, Kevin A.McCarthy, Guillaume Chabot-Couture
Vaccine
Brittany Hagedorn , Kevin McCarthy , Brittany L. Hagedorn, Alya Dabbagh, Kevin A. McCarthy
Vaccine
Brittany Hagedorn , Wedlock PT, Mitgang EA, Oron AP, Hagedorn BL, Leonard J, Brown ST, Bakal J, Siegmund SS, Lee BY
Vaccine
The emergent pathogen research program at IDM provides support to pandemic-preparedness and outbreak-response partners through data analysis, dynamical modeling, and genetic inference. Focus areas include recent outbreaks of Ebola, sylvatic reservoirs of vector-borne viruses, and transmission characteristics of seasonal flu.
Our Ebola research centers on characterizing the geographical spread of disease at different scales -- household, neighborhood, village, regional -- and relating to genetic and case-report data. The work elucidates the role of population sub-structure and the impact of social mobilization, behavior change, isolation facilities, and vaccination strategies. The goal is to provide timely support to operational and strategic partners in ongoing outbreaks.
Our influenza research targets improved pandemic preparedness through a more detailed understanding of the regional transmission characteristics of seasonal flu -- importation, spatial connectivity, and contact patterns (household, workplace, schools). Through our involvement in the Seattle Flu Study -- including geo-statistical modeling and phylogenetic inference -- our goal is to advance the real-time awareness of disease dynamics and to demonstrate the potential of novel diagnostic and intervention strategies.
External Links:
Some areas of work include:
- Role of Monkeys in Sylvatic Cycle of Chikungunya.
- Potential for Zika Virus to Establish a Sylvatic Cycle in the Americas.
- Identifying Spatiotemporal Dynamics of Ebola in Sierra Leone Using Virus Genomes.
Navideh Noori , Mollie Van Gordon , Brittany Hagedorn , Edward Wenger , Andre Lin Ouedraogo , Laura Skrip, Karim Derra, Mikaila Kaboré, Navideh Noori, Adama Gansané, Innocent Valéa, Halidou Tinto, Bicaba W. Brice, Mollie Van Gordon, Brittany Hagedorn, Hervé Hien, Benjamin M. Althouse, Edward A. Wenger, André Lin Ouédraogo
International Journal of Infectious Diseases
Laura A Skrip PhD, Jamie Bedson MSSc, Sharon Abramowitz PhD, Mohammed B Jalloh MPH, Saiku Bah MSc, Mohamed F Jalloh MPH, Ollin Demian Langle-Chimal MSc, Nicholas Cheney PhD, LaurentHébert-Dufresne PhD, Benjamin M Althouse PhD
The Lancet Planetary Health
Benjamin M Althouse, Samuel V Scarpino, Lauren Ancel Meyers, John W Ayers, Marisa Bargsten, Joan Baumbach, John S Brownstein, Lauren Castro, Hannah Clapham, Derek AT Cummings, Sara Del Valle, Stephen Eubank, Geoffrey Fairchild, Lyn Finelli, Nicholas Generous, Dylan George, David R Harper, Laurent Hébert-Dufresne, Michael A Johansson, Kevin Konty, Marc Lipsitch, Gabriel Milinovich, Joseph D Miller, Elaine O Nsoesie, Donald R Olson, Michael Paul, Philip M Polgreen, Reid Priedhorsky, Jonathan M Read, Isabel Rodríguez-Barraquer, Derek J Smith, Christian Stefansen, David L Swerdlow, Deborah Thompson, Alessandro Vespignani and Amy Wesolowski
EPJ Data Science
Poliomyelitis “polio” is an acute, viral, infectious disease spread from person to person primarily through contact with the contaminated stool of an infected person. According to the World Health Organization (WHO), 1 in 200 polio infections will result in permanent paralysis especially in children younger than 5 years old, who are the most likely to contract the virus. Although there is no cure, polio can be prevented through vaccination. Since the 1980s, vaccination efforts have reduced the polio burden by 99.9% from 350,00 cases in 1988 to 22 reported cases in 2017. With the help of organizations such as the WHO, U.S Centers for Disease control and Prevention, UNICEF, and the Bill and Melinda Gates Foundation more than 16 million children have been saved from paralysis thus ensuring that 80% of the world’s population now lives in polio-free regions. However, polio still exists in some of the world’s most complex regions, notably Afghanistan, Pakistan, and Nigeria, and until the number of cases reported equates to zero, the fight for eradication will not stop.
Our Mission
Our aim is to support polio eradication efforts from the sub-national to the global level by doing the following:
- Conducting policy-based research and computer simulations.
- Using advanced analytics and disease transmission models to project the impact of the strategies currently being used to fight the disease.
- Evaluate the impact that novel strategies could have before they are rolled out to the field.
http://polioeradication.org/polio-today/polio-prevention/the-virus/
Guillaume Chabot-Couture, Deputy Director, Research Programs
Hil Lyons, Research Manager
Joshua Proctor, Principal Research Scientist
Kevin McCarthy, Sr. Research Manager
Mike Famulare, Principal Research Scientist
Steve Kroiss, Sr. Research Scientist
Albert Lee, Research Scientist
Wesley Wong, Postdoctoral Research Scientist
Mike Famulare , Andrew L. Valesano, Mami Taniuchi, William J.Fitzsimmons, Mdm OhedulIslam, Tahmina Ahmed, Khalequ Zaman, Rashidul Haque, WesleyWong, Michael Famulare, Adam S.Lauring
ScienceDirect
Steve Kroiss , Guillaume Chabot-Couture , Mike Famulare , Kevin McCarthy , Hil Lyons , Steve J. Kroiss, Maiwand Ahmadzai, Jamal Ahmed, Muhammad Masroor Alam, Guillaume Chabot-Couture, Michael Famulare, Abdirahman Mahamud, Kevin A. McCarthy, Laina D. Mercer, Salman Muhammad, Rana M. Safdar, Salmaan Sharif, Shahzad Shaukat, Hemant Shukla, Hil Lyons
PLOS One
Mike Famulare , Kevin McCarthy , Guillaume Chabot-Couture , Michael Famulare, Christian Selinger, Kevin A. McCarthy, Philip A. Eckhoff, Guillaume Chabot-Couture
PLoS Biol. 2018
Steve Kroiss , Hil Lyons , Guillaume Chabot-Couture , Laina D. Mercer, Rana M. Safdar, Jamal Ahmed, Abdirahman Mahamud, M. Muzaffar Khan, Sue Gerber, Aiden O’Leary, Mike Ryan, Frank Salet, Steve J. Kroiss, Hil Lyons, Alexander Upfill-Brown, and Guillaume Chabot-Couture
BMC Medicine
Steve Kroiss , Mike Famulare , Hil Lyons , Kevin McCarthy , Guillaume Chabot-Couture , Steve J. Kroiss, Michael Famulare, Hil Lyons, Kevin A. McCarthy, Laina D. Mercer, Guillaume Chabot-Couture
Vaccine
Kevin McCarthy , Guillaume Chabot-Couture , Mike Famulare , Hil Lyons , Kevin A. McCarthy, Guillaume Chabot-Couture, Michael Famulare, Hil M. Lyons and Laina D. Mercer
BMC Medicine
Mike Famulare , Dr Mami Taniuchi, PhD, Michael Famulare, PhD, Khalequ Zaman, PhD, Md Jashim Uddin, MSc, Alexander M Upfill-Brown, MSc, Tahmina Ahmed, MSc, Parimalendu Saha, MSc, Rashidul Haque, PhD, Ananda S Bandyopadhyay, MBBS, Prof John F Modlin, MD, James A Platts-Mills, MD, Prof Eric R Houpt, MD, Mohammed Yunus, MBBS, Prof William A Petri Jr, MD
The Lancet Infectious Diseases
Kevin McCarthy , Guillaume Chabot-Couture , Kevin A. McCarthy, Guillaume Chabot-Couture, and Faisal Shuaib
A spatial model of Wild Poliovirus Type 1 in Kano State, Nigeria
Guillaume Chabot-Couture , Hil Lyons , Alexander M. Upfill-Brown, Arend Voorman, Guillaume Chabot-Couture, Faisal Shuaib, Hil M. Lyons
BMC Medicine
Guillaume Chabot-Couture , Alexandra E. Brown, Hiromasa Okayasu, Michael M. Nzioki, Mufti Z. Wadood, Guillaume Chabot-Couture, Arshad Quddus, George Walker and Roland W. Sutter
The Journal of Infectious Diseases
Mike Famulare , Stewart Chang , Michael Famulare, Stewart Chang, Jane Iber, Kun Zhao, Johnson A. Adeniji, David Bukbuk, Marycelin Baba, Matthew Behrend, Cara C. Burns and M. Steven Oberste
Journal of Virology
Mike Famulare , Michael Famulare
PLoS ONE
Daniel Klein , Bradley Wagner, Matthew Behrend, Daniel Klein, Alexander Upfill-Brown, Philip Eckhoff, and Hao Hu
PLoS ONE
Hil Lyons , Guillaume Chabot-Couture , Alexander Upfill-Brown, Hil Lyons, Muhammad A Pate, Faisal Shuaib, Shahzad Baig, Hao Hu, Philip Eckhoff, and Guillaume Chabot-Couture
BMC Medicine
Matthew R. Behrend, Hao Hu, Karima R. Nigmatulina, and Philip Eckhoff
International Journal of Infectious Diseases
The respiratory disease research program at IDM provides analytic support to research, policy, and implementation partners on a range of diseases, including pneumonia, RSV, and influenza.
Our pneumonia research centers on questions of local-elimination feasibility, critical community size for endemic transmission, and the role of herd protection from vaccination. To support these efforts, we use detailed mathematical models of pneumococcal colonization and transmission, which are calibrated to historical studies and recent trials that inform our understanding of family structure and strain-specific immunity.
More broadly, our research on respiratory pathogens, a leading cause of childhood mortality, has explored patterns of seasonality, severity, and co-infection for a variety of viral pathogens observed in hospital cases. That work has been extended to explore the expected impact of maternal and childhood vaccination strategies for RSV and to relate the predictive power of online search trends to regional epidemic characteristics.
Our influenza research targets improved pandemic preparedness through a more detailed understanding of the regional transmission characteristics of seasonal flu -- importation, spatial connectivity, and contact patterns (household, workplace, schools). Through our involvement in the Seattle Flu Study -- including geo-statistical modeling and phylogenetic inference -- our goal is to advance the real-time awareness of disease dynamics and to demonstrate the potential of novel diagnostic and intervention strategies.
External Links:
Some areas of work include:
- Seasonality of Respiratory Viruses Causing Hospitalizations for ARI (Vietnam).
- Identifying Transmission Routes of S.pneumoniae.
Navideh Noori , Mollie Van Gordon , Brittany Hagedorn , Edward Wenger , Andre Lin Ouedraogo , Laura Skrip, Karim Derra, Mikaila Kaboré, Navideh Noori, Adama Gansané, Innocent Valéa, Halidou Tinto, Bicaba W. Brice, Mollie Van Gordon, Brittany Hagedorn, Hervé Hien, Benjamin M. Althouse, Edward A. Wenger, André Lin Ouédraogo
International Journal of Infectious Diseases
B. M. ALTHOUSE, L. L. HAMMITT, L. GRANT, B. G. WAGNER, R. REID, F. LARZELERE-HINTON, R. WEATHERHOLTZ, K. P. KLUGMAN, G. L. RODGERS, K. L. O'BRIEN and H. HU
Epidemiology and Infection
Haedi DeAngelis, Samuel V. Scarpino, Meagan C. Fitzpatrick, Alison P. Galvani, Benjamin M. Althouse
JAMA Pediatrics
Benjamin M. Althouse and Samuel V. Scarpino
BMC Medicine
The TB research program at IDM provides analytical support to our research, policy, and implementation partners. These include analyses to identify priority areas for research, as well as impact estimation for interventions that can be used to develop strategic plans, target product profiles, and field studies. To support these efforts, we have developed a very flexible individual-based modeling software tool, EMOD-TB-HIV (which uses overlapping components with EMOD-HIV in order to capture the effects of co-infection and HIV treatment on TB progression), for which source code and documentation are freely available online, and training is available on request both through IDM and our research collaborator network.
Current priorities for our research agenda include:
- Use cases for emerging TB diagnostics, interventions to reduce vulnerability to TB (such as nutrition and smoking cessation.
- The role of social network structures in determining which interventions work best to accelerate reductions in TB incidence and burden.
Michelle A Bulterys, Bradley Wagner, Mael Redard-Jacot, Anita Suresh, Nira R. Pollock, Emmanuel Moreau, Claudia M. Denkinger, Paul K. Drain, Tobias Broger
Journal of Clinical Medicine
Stewart Chang , Stewart T. Chang, Violet N. Chihota, Katherine L. Fielding, Alison D. Grant, Rein M. Houben, Richard G. White, Gavin J. Churchyard, Philip A. Eckhoff, and Bradley G. Wagner
BMC Medicine
Stewart Chang , Prof Nicolas A Menzies, PhD, Gabriela B Gomez, PhD, Fiammetta Bozzani, MSc, Susmita Chatterjee, PhD, Nicola Foster, MPH, Ines Garcia Baena, MSc, Yoko V Laurence, MSc, Prof Sun Qiang, PhD, Andrew Siroka, PhD, Sedona Sweeney, MSc, Stéphane Verguet, PhD, Nimalan Arinaminpathy, DPhil, Andrew S Azman, PhD, Eran Bendavid, MD, Stewart T Chang, PhD, Prof Ted Cohen, DPH, Justin T Denholm, PhD, David W Dowdy, MD, Philip A Eckhoff, PhD, Jeremy D Goldhaber-Fiebert, PhD, Andreas Handel, PhD, Grace H Huynh, PhD, Marek Lalli, MSc, Hsien-Ho Lin, ScD, Sandip Mandal, PhD, Emma S McBryde, PhD, Surabhi Pandey, PhD, Prof Joshua A Salomon, PhD, Sze-chuan Suen, MS, Tom Sumner, PhD, James M Trauer, MBBS, Bradley G Wagner, PhD, Prof Christopher C Whalen, MD, Chieh-Yin Wu, MS, Delia Boccia, PhD, Vineet K Chadha, MD, Salome Charalambous, PhD, Daniel P Chin, MD, Prof Gavin Churchyard, PhD, Colleen Daniels, MA, Puneet Dewan, MD, Lucica Ditiu, MD, Jeffrey W Eaton, PhD, Prof Alison D Grant, PhD, Piotr Hippner, MSc, Mehran Hosseini, MD, David Mametja, MPH, Carel Pretorius, PhD, Yogan Pillay, PhD, Kiran Rade, MD, Suvanand Sahu, MD, Lixia Wang, MS, Rein M G J Houben, PhD, Michael E Kimerling, MD, Richard G White, PhD, Anna Vassall, PhD
The Lancet
Stewart Chang , Dr Rein M G J Houben, PhD, Nicolas A Menzies, PhD, Tom Sumner, PhD, Grace H Huynh, PhD, Nimalan Arinaminpathy, PhD, Jeremy D Goldhaber-Fiebert, PhD, Hsien-Ho Lin, PhD, Chieh-Yin Wu, MS, Sandip Mandal, PhD, Surabhi Pandey, PhD, Sze-chuan Suen, MS, Eran Bendavid, MD, Andrew S Azman, PhD, David W Dowdy, PhD, Nicolas Bacaër, PhD, Allison S Rhines, PhD, Prof Marcus W Feldman, PhD, Andreas Handel, PhD, Prof Christopher C Whalen, MD, Stewart T Chang, PhD, Bradley G Wagner, PhD, Philip A Eckhoff, PhD, James M Trauer, PhD, Justin T Denholm, PhD, Prof Emma S McBryde, PhD, Ted Cohen, DPH, Prof Joshua A Salomon, PhD, Carel Pretorius, PhD, Marek Lalli, MSc, Jeffrey W Eaton, PhD, Delia Boccia, PhD, Mehran Hosseini, MD, Gabriela B Gomez, PhD, Suvanand Sahu, MD, Colleen Daniels, MA, Lucica Ditiu, MD, Daniel P Chin, MD, Lixia Wang, MS, Vineet K Chadha, MD, Kiran Rade, MPhil, Puneet Dewan, MD, Piotr Hippner, MSc, Salome Charalambous, PhD, Prof Alison D Grant, Prof Gavin Churchyard, PhD, Yogan Pillay, PhD, L David Mametja, MPH, Michael E Kimerling, MD, Anna Vassall, PhD, Richard G White, PhD
The Lancet
Daniel Klein , Grace H Huynh, Daniel Klein, Daniel P Chin, Bradley G Wagner, Philip A Eckhoff, Renzhong Liu, and Lixia Wang
BMC Medicine
Daniel Klein , Grace H Huynh, Daniel Klein, Daniel P Chin, Bradley G Wagner, Philip A Eckhoff, Renzhong Liu, and Lixia Wang
BMC Medicine