Philip Welkhoff leads all research efforts at IDM and is the Senior Director of Research of the IDM disease modeling team at Intellectual Ventures’ Global Good Fund. He received his Ph.D. from Princeton University in Applied and Computational Mathematics,and has dual undergraduate degrees in Mathematics and Aerospace Engineering from the University of Texas, Austin. At Princeton, Philip’s work focused on computational neuroscience and biophysics-motivated models of decision making. Also while at Princeton, he began working on malaria and mathematical models of disease transmission. Philip’s interest in disease transmission, particularly malaria, began early on. As a child, he frequently suffered from malaria while growing up at a humanitarian hospital on the north coast of Haiti. In 2009, Philip received a SpecialAchievement Award by a Hertz Fellow for his work on malaria modeling. He also serves on the board of directors for the Fannie and John Hertz Foundation and as an interviewer for its graduate fellowship program. Additionally, he serves as an external reviewer for the Bill and Melinda Gates Foundation (BMGF) and as a pro bono external advisor for BMGF programs in Global Health and Global Development. Beyond modeling disease eradication, Philip’s research interests include technologies for improved public health in the developing world, as well as other global development issues,such as vaccine delivery, developing world nutrition and agriculture, and improved sanitation.

Biography

Philip Welkhoff leads all research efforts at IDM and is the Senior Director of Research of the IDM disease modeling team at Intellectual Ventures’ Global Good Fund. He received his Ph.D. from Princeton University in Applied and Computational Mathematics,and has dual undergraduate degrees in Mathematics and Aerospace Engineering from the University of Texas, Austin. At Princeton, Philip’s work focused on computational neuroscience and biophysics-motivated models of decision making. Also while at Princeton, he began working on malaria and mathematical models of disease transmission. Philip’s interest in disease transmission, particularly malaria, began early on. As a child, he frequently suffered from malaria while growing up at a humanitarian hospital on the north coast of Haiti. In 2009, Philip received a SpecialAchievement Award by a Hertz Fellow for his work on malaria modeling. He also serves on the board of directors for the Fannie and John Hertz Foundation and as an interviewer for its graduate fellowship program. Additionally, he serves as an external reviewer for the Bill and Melinda Gates Foundation (BMGF) and as a pro bono external advisor for BMGF programs in Global Health and Global Development. Beyond modeling disease eradication, Philip’s research interests include technologies for improved public health in the developing world, as well as other global development issues,such as vaccine delivery, developing world nutrition and agriculture, and improved sanitation.

Publications

Monday, June 12, 2017

​A household-level model of malaria transmission is developed to understand the role of reactive case detection in malaria elimination in diverse transmission settings.

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Wednesday, April 26, 2017
​​​​Epidemics on modern human mobility networks are complex, but we demonstrate that population-level dynamics can be summarized with a parsimonious model based on space-fractional diffusion.​
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Tuesday, December 27, 2016

Mathematical modeling is used to evaluate mosquito gene-drive approaches in realistically seasonal spatial settings and to determine constraints on gene-construct parameters and release strategies.

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Wednesday, November 23, 2016

​In the Lake Kariba region of Zambia, villages with high and low malaria burden are interconnected, making elimination potentially very challenging.

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Wednesday, November 16, 2016

A star-shaped, drug-containing material is packaged into a capsule that dissolves in the stomach and assumes a shape that cannot pass further down the intestine.

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Tuesday, November 1, 2016

The post-2015 End TB Strategy sets global targets of reducing tuberculosis incidence by 50% and mortality by 75% by 2025.

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Thursday, October 6, 2016

​​The post-2015 End TB Strategy proposes targets of 50% reduction in TB incidence and 75% reduction in mortality from TB by 2025.

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Wednesday, September 21, 2016

A new computational model was developed to investigate the probability of fertilization over a range of overdispersion parameters and male gamete exploration rates.

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Tuesday, April 5, 2016
Could future generations could be protected from HIV using a prevention "age fence," analogous to the ring-fencing strategies used to control the spread of smallpox?
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Thursday, January 28, 2016
This publication examines new stochastic simulations of a prototypical infection on the dense, highly-connected United States air travel network.
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Thursday, January 14, 2016
Presumptively administering antimalarial drugs to whole populations will effectively clear infection but can lead to overtreatment.
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Thursday, November 5, 2015
The purpose of this study was to assess the public health impact and cost-effectiveness of routine use of the RTS,S/AS01 vaccine in Africa.
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Friday, September 18, 2015
Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa.
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Tuesday, September 8, 2015

In many countries health system data remain too weak to accurately enumerate Plasmodium falciparum malaria cases.

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Friday, July 3, 2015

In a longitudinal malaria research study, we found that low-density infections were common and primarily contribute to onward malaria transmission in a high and seasonal transmission setting.

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Thursday, July 2, 2015

Migrant populations such as mine workers contributed to the spread of HIV in sub-Saharan Africa.

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Wednesday, July 1, 2015
Modern society has been transformed by the digital revolution through cellular phones for communication, remote sensing of weather and other terrestrial data, cheap and plentiful digital computation a
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Wednesday, June 3, 2015
Individuals with subpatent infections form a substantial portion of the infectious reservoir of malaria at all transmission intensities.
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Thursday, May 21, 2015

In the last 20 years, China ramped up a DOTS (directly observed treatment, short-course)-based tuberculosis (TB) control program with 80% population coverage, achieving the 20

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Thursday, May 14, 2015

Since the original Ross–Macdonald formulations of vector-borne disease transmission, there has been a broad proliferation of mathematical models of vector-borne disease,

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Thursday, May 7, 2015

Traditional methods for estimating malaria transmission based on mosquito sampling are not standardized and are unavailable in many countries in sub-Saharan Africa.

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Tuesday, April 21, 2015

In the last 20 years, China ramped up a DOTS (directly observed treatment, short-course)-based tuberculosis (TB) control program with 80% population coverage, achieving the 2015 Millennium Developm

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Sunday, March 1, 2015
The development and application of quantitative methods to understand disease dynamics and plan interventions is becoming increasingly important in the push toward eradication of human infectious dise
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Wednesday, January 7, 2015

A pre-erythrocytic vaccine could provide a useful tool for burden reduction and eventual eradication of malaria.

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Thursday, December 11, 2014

Mathematical models are a helpful tool for testing assumptions and elucidating the quantitative implications of disease features.

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Monday, December 1, 2014
Using an individual-based mathematical model, we quantified the impact of EAG campaigns in terms of probability of elimination, reduction in polio transmission and age stratified immunity levels.
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Saturday, November 8, 2014
With recent increase in affordability and accessibility of high-performance computing (HPC), the use of large stochastic models has become increasingly popular for its ability to accurately mimic the
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Thursday, July 31, 2014

Decision makers need efficient algorithms to draw meaningful conclusions from detailed stochastic simulations with respect to a goal-oriented objective.

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Wednesday, June 4, 2014

One of the challenges facing the Global Polio Eradication Initiative is efficiently directing limited resources, such as specially trained personnel, community outreach activities, and satellite va

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Tuesday, April 22, 2014

Understanding the environmental conditions of disease transmission is important in the study of vector-borne diseases.

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Wednesday, January 1, 2014

Recent scientific findings have demonstrated the efficacy and effectiveness of antiretroviral therapy (ART) for preventing transmission in heterosexual partnerships.

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Tuesday, October 22, 2013

To examine forces that drive vaccination policy to eradicate wild- and vaccine-derived poliovirus, and to focus on the efficacy of vaccines to support decision-making and further research, we searc

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Wednesday, August 28, 2013

The difficulty of choosing a strategy for allocating transmission-blocking interventions stems from an incomplete picture of the epidemiological drivers of generalized HIV epidemics, such as the ep

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Thursday, May 9, 2013

Contact rates tend to increase with density but saturate at higher density.

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Wednesday, May 1, 2013

This article describes IDM's malaria model which combines detailed vector population dynamics that interact with the human population, and a microsimulation for human i

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Monday, April 15, 2013

The impact of potential malaria vaccines is studied utilizing IDM's malaria model and EMOD software which couple a detailed description of the vector lifecycle with a comprehensive, mechanistic

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Monday, February 4, 2013

Mathematical models of ART and PrEP have been used to assess the risk of drug resistance on the individual and population level.

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Saturday, December 15, 2012

Malaria exhibits tremendous antigenic variation, both within single infections and across the parasite population, and variant-specific exposure is a strong predictor of future responses.

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Wednesday, December 12, 2012

Public health campaigns attempt to drive the effective reproduction number close to unity.

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Wednesday, September 19, 2012

This paper presents a mechanistic intrahost model and model-based simulations of the dynamics of P. falciparum.

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Sunday, June 17, 2012

The EMOD model for HIV was compared to several other HIV models in an article by Eaton et al. published in PLoS Medicine.

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Monday, October 17, 2011

Malaria is an important global health issue and basic vector ecology is a fundamental driver of transmission patterns, and changes in land usage or land modification can dramatically change transmi

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Tuesday, January 25, 2011

Mathematical modeling can guide all stages of malaria elimination and eradication by synthesizing information, quantifying uncertainty, and extrapolating current knowledge.

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